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1:
What’s New
Basic Overview
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2:
Photosensitizers
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3:
Photosensitizers continued
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4:
Light sources
Applications of PDT
References
Contact information
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Science has yet to tackle one of the remaining and most formidable foes
of humanity; Cancer. This disease kills thousands of people every year
and though many types of therapy exist they are long, expensive and
are usually accompanied with unpleasant side effects. Of recent a movement
out from this dark reality has emerged a possibility of a brighter future
in the world of cancer research. Though Photodynamic Therapy is in its
early stages of research it has shown to be quite effective in eradicating
cancerous lesions quickly. The advantage that Photodynamic Therapy (PDT)
has over other present methods of cancer treatment is that it does not
require extensive operations or harmful drugs. It is this advantage
that is so intriguing and has thus caught the eye of many cancer researchers
and patients alike around the world.
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Photodynamic Therapy is the use of light to activate light sensitive
molecules (photosensitizers) such as porphyrins to eliminate cancerous
tumors. Specifically PDT involves directing and accumulating photosensitizers
into a specific region of the body (cancerous tissue). Following the
localization of these photosensitive molecules a light source containing
the appropriate wavelength to sufficiently excite the photosensitizer
is introduced. Activation of the photosensitizer causes the generation
of “active molecular species, such as free radicals and singlet
oxygen that are toxic to cells and tissues”.(1)
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Figure 1.
Photons from light source are absorbed by photosensitizer thus
it becomes excited (activated). In an effort to decay and lower
its electronic state it will initiate photochemical reactions
producing free radicals.(1) cells produce prostoglandins to close
blood vessels to reduce radical poisoning. This causes mitochondria
to starve and die. Without mitochondria cells in affected region
lack ATP and die.
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