Research Interests

Our RNA Cancer Research Group focuses on understanding the post-transcriptional regulation of mammalian gene expression, particularly on how the mechanisms are deregulated in cancer cells.  We are specifically interested in identifying and studying a poorly understood group of mammalian enzymes called endoribonucleases which are involved in the biogenesis of messenger RNAs (mRNAs), microRNAs, and other small non-coding RNAs.  We anticipated that a better understanding of the biological functions and properties of these enzymes will lead to the development of novel molecular approaches for the treatment of human cancers and other human diseases.