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IZZIE: "I can't just... I gotta do something to help. But thank you... thank you for saying it’s gonna be okay, even if that's just what you say."
MIRANDA: [to the interns] "I've been gone for two weeks. Two weeks and you ran off two residents? I've got people phoning me at home, screaming, telling me my interns are a bunch of Rosemary's Babies. Nobody wants you! Do you think I have time for this? I'm pregnant. I'm supposed to be on bed rest. I'm supposed to be growing a human being. I'm supposed to be calm. Do I look calm? Did I raise you fools to be pariahs?"
MEREDITH: "Okay. The man I love has a wife and then he chooses her over me. Then the wife takes my dog. Well, she didn't actually take my dog. I gave it to her. But I didn't mean to give it to her, I meant to give it to him, and that doesn't change the fact that she's got Derek. And my McDog. She's got my McLife! What have I got? I can't even remember the last time we kissed. Because you never think the last time is the last time. You think you have forever, but you don't. Plus my conditioner decided to stop working and I think I have brittle bones. I need something to happen. I just need a sign. I need a reason to go on. I need some hope, and in the absence of hope, I need to stay in bed and feel like I might die today."
GEORGE: [to Meredith] "Hi. I... I know I'm not a world-renowned surgeon, and... I know I'm not a lot of things you've gone for in the past. I know that. But... I would never leave you. I would never hurt you. And I will never stop loving you."
MEREDITH: [narrating] "In hospitals, they say you know when you’re going to die. Some doctors say it’s a look patients get in their eyes. Some say there’s a scent, a certain smell. Some say it’s some kind of sixth sense. When the great beyond is headed for you, you feel it coming. If today were your last day on Earth? How would you spend it?"
GEORGE: [narrating] "Karma. One way or another it will leave us to face ourselves. We can look our karma in the eye or we can wait for it to sneak up from behind. But karma will always find us. The truth is, as surgeons, we have more chances than most to set the balance in our favor. Yet no matter how hard we try we can't escape our karma. It follows us home. I guess we can't really complain about our karma. It's not an affair. It's not unexpected. It just... evens the score. And even when we're about to do something that we know will tempt karma to bite us in the ass... well, it goes without saying. We do it anyway."
PRESTON: [enters his apartment] "I am Preston Burke. I am a widely renowned cardio-thoracic surgeon. I am a professional and moreover I am a good, kind person. I am a person that cleans up after himself. I am a great cook. And you? You are an unbelievable slob. A slovenly, angry intern. I am Preston Burke. And you... are the most competitive, guarded, stubborn... the most challenging person I have ever met. And I love you. Why the hell won't you just let me?
MEREDITH: "Okay. Not okay." [silence] "Well, I need one of you to tell me what this means exactly. Because I think I know what it means, but I tend to be glass half-empty these days, so I don’t trust what I think it means. Because what I think it means is that if the bomb were to explode over the oxygen line, the whole hospital could blow up. That’s just crazy right?"