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Meredith puts the Grey in Grey's Anatomy.

No, she actually does. It's her last name, and the series takes its name from the classic anatomy textbook Henry Gray's Anatomy of the Human Body, commonly known as Gray's Anatomy. She narrates the show (with the exception of one episode), usually with voiceovers at the beginning and conclusion of the program.

Meredith is the daughter of Dr. Ellis Grey, who suffers from advanced Alzheimer's disease and was a close friend of Dr. Richard Webber, the chief of surgery at Seattle Grace Hospital. She began a love affair with Dr. Derek Shepherd the night before she began her career as an intern, not knowing he was a surgeon at the hospital. She falls in love with him only to discover he is married when his wife Addison comes to join the staff at Seattle Grace.

She shares her house, which once belonged to her mother, with fellow intern Izzie. George used to live with her as well, but moved out following his disastrous one night stand with Meredith. A talented doctor and a graduate of Dartmouth College, Meredith frequently battles self-doubt and mild depression over the respective situations with her mother and Derek.

 Meredith Grey

Derek is a renowned brain surgeon who we are led to believe moved to Seattle from New York a little bit before the series debuted. He and intern Meredith Grey met and slept together during the pilot, with their romance blossoming soon after.

Derek is married to Dr. Addison Montgomery Shepherd, who he left in New York after finding her in bed with his best friend Mark, a plastic surgeon. Addison joining the staff at Seattle Grace during Season One resulted in constant conflict for Derek as he struggles to repair his marriage and deal with his feelings for Ms. Grey.

Dr. Shepherd was nicknamed "McDreamy" by the female interns at Seattle Grace. The man has some amazing hair. He and Dr. Preston Burke are among the hospital's top surgeons and there has been occasional friction other which one the chief, Dr. Richard Webber, will name as his successor.

Dr. Derek Shepherd

The chief of surgery at Seattle Grace Hospital. He strives to balance both the medicinal and financial sides of running such an important institution.

Richard often refers to the financial implications of things, such as Derek punching out Mark (and risking his "$2 million-per-year hand"), or why he cannot prevent the nurses union from striking.

In Season One, he had Derek operate on a tumor that was pressing on his optic nerve, emphasizing that the surgery be downplayed so his position as chief surgeon wouldn't be jeopardized. Dr. Webber made a full and speedy recovery and retained his post.

Considered a mentor to both Dr. Burke and Dr. Shepherd, two of his hospital's elite surgeons and both of whom aspire to succeed him as chief of surgery. Richard is also a close friend of Dr. Ellis Grey, mother of Meredith. Recently it was revealed that he and the elder Grey may have had an affair.

 Dr. Richard Webber

He has harbored a secret crush on Meredith, with whom he shares a house, from day one. George also has a host of other insecurities. His positive outlook on life, and the fact that he is more emotional than most men, often lead to conflict with other doctors.

George doesn't fit in with his own family, either. A Thanksgiving hunting trip resulted in a George unloading a lot of emotional baggage during a conversation with his blue-collar dad and brothers (one of whom later shot the dad, forcing George to operate).

A friend and confidant of Izzie, George won praise among the entire hospital staff for saving a man's life in an elevator during a power failure. With Dr. Burke talking him through it, George stopped the bleeding in a patient's heart single-handedly after Alex choked under pressure.

He recently admitted his feelings for Meredith and ended up sleeping with her during a period of peak vulnerability for both. After some disastrous fallout, he moved out of her house and onto Dr. Burke's sofa.

George O'Mally

She's abrasive, afraid of commitment, doesn't "do" emotion and is extremely competitive about getting the "cool" surgeries. She is of Korean descent and is a native of Beverly Hills, Calif. Cristina graduated from the Stanford University School of Medicine and maintains a love-hate relationship with her mother.

Despite being his polar opposite in many respects, she began dating Dr. Preston Burke during Season One. She became pregnant, only to have him break off their relationship for professional reasons. Cristina planned to have an abortion without telling Burke, but changed her mind after talking to a pregnant patient. She later collapsed during a surgery with Burke, and was diagnosed with an ectopic pregnancy, which was surgically terminated.

Despite his emotional and physical trauma, she and Burke got back together soon after. The evolution of Cristina's relationship with Dr. Burke is a focal point of Grey's Anatomy. She only told Burke she loved him while he was asleep, and didn't give up her apartment for months after moving in with him. Cristina is particularly close to Meredith, although she is also friends with George and Izzie.

Cristina Yang

A statuesque blonde, Isobel "Izzie" Stevens put herself through medical school by modeling. Underwear. Wow.

When this fact is publicized by Dr. Alex Karev, who pins pictures of her up in the locker room, Izzie flys off the handle. She later warms up to Alex, however, and dates him briefly before catching him sleeping with a nurse and breaking it off. They are now back together, subject to change at any second.

At first, Izzie butted heads with Meredith over the latter's relationship with Dr. Shepherd. Izzie initially believed it was a plot for Dr. Grey to get ahead of her fellow interns, but the two have become good friends. They live in the same house, one that was also inhabited by George until the most recent episode.

When meeting a pregnant teenage girl from her hometown (outside Seattle), Izzie revealed that she, too, had a daughter at 16. Her daughter, who is now 12, was adopted and now lives in Santa Barbara, Calif. Izzie has shown an interest in surgery involving infants and extremely young children, the specialty of Dr. Addison Shepherd.

 Isobel "Izzie" Stevens

The interns' boss. Also known, affectionately, as the Nazi. She's bad-ass.

From the moment she first met the interns, she made her presence known by telling them not to bother sucking up, because she already hates them, "and that is not going to change." Not surprisingly, there has been no sucking up -- or talking back -- to Miranda ever since.

Miranda's softer side has made more frequent appearances of late, however, as she became pregnant and gave birth to her first child. At first, she kept a low profile regarding the pregnancy, but her cover was blown after she turned down an elite fellowship opportunity and Dr. Webber became convinced she was quitting.

Dr. Bailey reached an emotional breaking point when her husband was hospitalized with severe head trauma, sustained in a car wreck on his way to the hospital. George helped her stay calm through the birthing process, while Derek was able to repair the damage to her husband's brain.

All during a CODE BLACK!

Dr. Miranda Bailey

No one dies on this man's watch. He's a brilliant heart surgeon and a kind, compassionate person. The consummate professional, and a great cook to boot. What's not to love about Dr. Burke?

Preston grew up in Alabama, where his mother owns a restaurant. He is the chief cardio-thorasic surgeon at Seattle Grace, and is known for his grace under pressure as well as his incredible scalpel skills. Seriously, you cannot rattle the guy in the operating room or in real life. Cristina Yang has tried during her romance with the handsome physician, which he initially broke off because of concern for his reputation.

The polar opposites are back together now, however, and Cristina recently moved into his apartment. The evolution of their relationship despite many personality differences has been a focal point of Grey's Anatomy in recent weeks. Preston has also warmed up to Derek Shepherd, despite initial friction between the two surgical all-stars.

 Dr. Preston Burke

The arrogant, handsome intern who is both repulsive and irresistible to Izzie. The two have an on-again, off-again relationship that is currently on, following a hiatus caused by Alex getting caught sleeping with a nurse -- in an attempt to regain confidence after "performance anxiety" problems with Izzie.

A former wrestler at the University of Iowa, he often tries to act more tough and aloof than he actually is. He and George O'Malley have never gotten along, partly due to general personality clashes and also because Alex indirectly gave him syphilis (in Season One, George dated and slept with a nurse that Alex shagged).

After he and a visiting surgeon (Mark, the former best friend of Derek and lover of Addison) discussed his career prospects, Alex expressed interest in becoming a plastic surgeon.


 Alex Karev

One of the most compelling characters on the show. When viewers were first introduced to Mrs. McDreamy, she was the villain, arriving in the Emerald City just in time to ruin Meredith's relationship with her husband. It turns out that Derek left New York for Seattle after catching her in bed with Mark, a plastic surgeon and his best friend -- a fact he conveniently withheld from Meredith.

While she gave Derek the chance to sign divorce papers and end things between them for good, he declined. They have slowly begun to patch things up, although much guilt and resentment remains. The reappearance of Mark, who tried to lure her back to New York, did not help matters. Addison also hates living in Derek's trailer, and the fact that he adopted Meredith's dog.

Addison specializes in surgery involving extremely young children, including those still in the womb. She has become a mentor to Izzie, and a commanding presence throughout the traditionally male-dominated hospital.

Dr. Addison Shepherd