CHOW H. LEE
Biochemistry & Molecular Biology
University of Northern BC
Prince George, BC, V2N 4Z9, CANADA
Tel: (250) 960-5413
Fax: (250) 960-5845
Photos with Students
Ph.D., Molecular Cell Biology, Flinders University, AUSTRALIA; 1992.
Dept of Advanced Therapeutics, BC Cancer Agency, Vancouver, BC, CANADA; 1997-1998.
McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, USA; 1996-1997.
Ontario Cancer Institute, Toronto, Ontario, CANADA; 1991-1996.
Associate Professor: Department of Chemistry, UNBC; 2003-present.
Affiliate Associate Professor: Department of Biochemistry & Molecular Biology, Faculty of Medicine, UBC; 2004-present.
National Cancer Institute of Canada Research Scientist; 2002-2008.
Visiting Scholar: Department of Molecular, Cellular & Developmental Biology, YALE UNIVERSITY, New Haven, USA; 2003.
Assistant Professor: Department of Chemistry, UNBC; 1999-2003.
Eberding A, Rehaume V, Lee CH. (2004) Detection of mRNA degradation intermediates in tissues using 3’-end poly(A)-tailing polymerase chain reaction method. Anal. Biochem. (in press).
Lee CH. (2004) Drug resistance in cancer therapy: Reversing agents for ABC drug transporters. Curr. Med. Chem. – Anti-Cancer Agents 4: 1-10.
Lee CH, Ling V. (2003) Superinduction of P-glycoprotein messenger RNA in vivo
in presence of transcriptional inhibitors. J. Exp. Ther. Oncol. 3: 14-26.
Lee CH, Edwards AM. (2003) Effects of estrogens and other growth-stimulatory
Agents on expression of c-fos and c-myc protooncogenes in primary rat
hepatocytes. Arch. Toxicol. 77: 150-159.
Lee CH, Cragoe EJ Jr, Edwards AM. (2003) Control of hepatocyte DNA synthesis
by intracellular pH and its role in the action of tumor promoters. J. Cell. Physiol.
Lee CH. (2002) Differential regulation of P-glycoprotein genes in primary rat
hepatocytes by collagen sandwich and drugs. J. Cell. Biochem. 86: 12-20.
Lee CH, Edwards AM. (2002) Structural specificity of steroids in stimulating hepatocyte DNAsynthesis and protooncogenes expression in primary culture. J. Steroid Biochem. Mol. Biol. 81: 25-36.
Lee CH. (2001) Induction of P-glycoprotein mRNA transcripts by cycloheximide in
animal tissues: Evidence that class I Pgp is transcriptionally regulated whereas
class II Pgp is post-transcriptionally regulated. Mol. Cell. Biochem. 216: 103-110.
Lee CH, Edwards AM. (2001) Stimulation of DNA synthesis and c-fos messenger
RNA expression in primary rat hepatocytes by estrogens. Carcinogenesis 22:
Lee CH, Edwards AM. (2001) Stimulation of DNA synthesis by tumour promoters
in primary rat hepatocytes is not mediated by arachidonic acid metabolites. J.
Cell. Physiol. 187: 336-344.
Kim NC, Wallis AE, Lee CH, de Menezes DL, Sartor J, Dragowska WH, Mayer L.
(2000) Effects of Bcl-2 modulation with G3139 antisense oligonucleotides on
human breast cancer cells are independent of inherent Bcl-2 protein expression.
Breast Cancer Res. Treat. 63: 199-212.
Lee CH, Leeds P, Ross J. (1998) Purification and characterization of a polysome
associated endoribonuclease that degrades c-myc mRNA in vitro. J. Biol. Chem.
Lee CH, Bradley G, Ling V. (1998) Increased P-glycoprotein messenger RNA
stability in rat liver tumors in vivo. J. Cell. Physiol. 177: 1-12.
Lee CH, Bradley G, Ling V. (1995) Overexpression of the class II P-glycoprotein
gene in primary rat hepatocyte culture: Evidence for increased mRNA stability.
Cell Growth & Differ. 6: 347-354.
Zhang J-T, Lee CH, Duthie M, Ling V. (1995) Topological determinants of internal
transmembrane segments in P-glycoprotein sequences. J. Biol. Chem. 270: 1742-
Lee CH, Bradley G, Ling V. (1994) Expression of P-glycoprotein in normal and
malignant rat liver cells. Cold Spring Harbor Symp. Quant. Biol. 59: 607-615.
Lee CH, Bradley G, Zhang J-T, Ling V. (1993) Differential expression of P-
glycoprotein genes in primary rat hepatocyte culture. J. Cell. Physiol. 157: 392-
Articles Submitted or In Preparation:
Bergstrom K, Lee CH. Evidence for two distinct endoribonucleases capable of cleaving coding region determinant of c-myc mRNA in vitro.
Bergstrom K, Urquhart J, Tafech A, Lee CH. Characterization and purification of PAC-2, a mammalian polysome-associated endoribonuclease that degrades c-myc mRNA in vitro.
Bergstrom K, Urquhart JC, Tafech A, Lee CH. PAC-2, a mammalian polysome-associated endoribonuclease that degrades c-myc mRNA in vitro is a SNAP receptor protein.
Lee CH, Rehaume V, Shandro J. Identification of in vivo P-glycoprotein mRNA decay intermediates in normal liver but not in liver tumours.
CHEM 204 - Biochemistry I (Introductory Biochemistry)
CHEM 221 - Organic & Biochemistry Lab
CHEM 306 - Biochemistry II (Intermediary Metabolism)
CHEM 307 - Biochemistry III (Proteins & Nucleic Acids)
CHEM 308 - Biochemistry & Molecular Biology Lab
CHEM 405/605 - Topics in Biochemistry (Basic Science of Oncology)
CHEM 405 - Topics in Biochemistry (Biochemistry of RNA)
CHEM 499 - Independent Study/Research Project
CHEM 705 - Cell Culture & Cell Biology Techniques (Practical & Theory)
CHEM 699 - Protein Purification (Practical & Theory)
CHEM 699 - Bioinformatics (RNA & Protein)